Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases.

ABSTRACT: Microbial translocation is a significant contributor to chronic inflammation in people living with HIV (PLWH) and is associated with increased mortality and morbidity in individuals treated for long periods with antiretrovirals. The use of therapeutics to treat microbial translocation has yielded mixed effects, in part, because the species and mechanisms contributing to translocation in HIV remain incompletely characterized. To characterize translocating bacteria, we cultured translocators from chronically SIV-infected rhesus macaques. Proteomic profiling of these bacteria identified cytosine-specific methyltransferases as a common feature and therefore, a potential driver of translocation. Treatment of translocating bacteria with the cytosine methyltransferase inhibitor decitabine signifi

SUBMITTER: Flynn JK 

PROVIDER: S-EPMC11471372 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature