Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer.

ABSTRACT:

Background

Tumor mRNA vaccines have been identified as a promising technology for cancer therapy in multiple cancer types, while their efficacy in thyroid cancer (THCA) is unclear. Immunotyping is strongly associated with the immune microenvironment and immune status in cancer, thus it is important in vaccination and therapeutic response. This study is to identify potential valuable antigens and novel immune subtypes of THCA for immune landscape construction, thus screening patients suitable for mRNA vaccination.

Methods

The clinical information and gene expression files of 568 THCA cases were obtained from the TCGA dataset. The DNA copy number variation and the somatic mutation of THCA were visualized by the cBioPortal database. TIMER was used to investigate the immune infi

SUBMITTER: Wang X 

PROVIDER: S-EPMC11471445 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature