Bioactive stem cell-laden 3D nanofibrous scaffolds for tissue engineering.

ABSTRACT: This study presents biomimetic nanoscaffolds composed of electrospun polycaprolactone-collagen (PCL-Coll) nanofibers, loaded with bioactive Arnebia euchroma (AE) extract and stem cells, to develop cell-based tissue engineering constructs. The incorporation of AE extract, known for its antioxidant and anti-inflammatory properties, into the PCL-Coll nanofibers resulted in nanoscaffolds denoted as PCL-Coll/AE₀, PCL-Coll/AE₅, PCL-Coll/AE₁₀, and PCL-Coll/AE₁₅, corresponding to AE extract concentrations of 0.0, 5.0, 10.0, and 15.0 wt%, respectively. The PCL-Coll/AE nanoscaffolds exhibited high porosity values of 62.81 ± 4.78 %, 59.9 ± 2.10 %, 52.44 ± 2.66 %, and 46.32 ± 1.35 %, respectively, thereby providing an optimal 3D environment for cell attachme

SUBMITTER: Natouri O 

PROVIDER: S-EPMC11471473 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature