Itaconate induces tolerance of <i>Staphylococcus aureus</i> to aminoglycoside antibiotics.

ABSTRACT:

Introduction

Staphylococcus aureus is one of the chief pathogens that cause chronic and recurrent infections. Failure of the antibiotics to curb the infections contributes to relapse and is an important reason for the high mortality rate. Treatment failure may also be due to antibiotic tolerance. Accumulating evidence suggests that t the host immune environment plays an important role in inducing antibiotic tolerance of S. aureus, but research in this area has been limited.

Methods

In this study,the minimum inhibitory concentration (MIC) of the antibiotics against S. aureus was determined using the standard broth microdilution method.The study evaluated whether itaconate induces antibiotic tolerance in S. aureus through an antibiotic bactericidal

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11471559 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature