Human Claustrum Connections: Robust In Vivo Detection by DWI-Based Tractography in Two Large Samples.

ABSTRACT: Despite substantial neuroscience research in the last decade revealing the claustrum's prominent role in mammalian forebrain organization, as evidenced by its extraordinarily widespread connectivity pattern, claustrum studies in humans are rare. This is particularly true for studies focusing on claustrum connections. Two primary reasons may account for this situation: First, the intricate anatomy of the human claustrum located between the external and extreme capsule hinders straightforward and reliable structural delineation. In addition, the few studies that used diffusion-weighted-imaging (DWI)-based tractography could not clarify whether in vivo tractography consistently and reliably identifies claustrum connections in humans across different subjects, cohorts, imaging methods, and con

SUBMITTER: Wendt J 

PROVIDER: S-EPMC11471578 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature