Common mental disorders and risk of female infertility: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Female infertility is a global issue that impacts on public health seriously and many mental disorders are observed in infertility groups.

Methods

To investigate the casual relationship between those, genome-wide association studies summary data of anxiety disorder (n=9,897), broad depression (n=322,580), major depressive disorder (n=480,359 and n=500,199), bipolar disorder (n=51,710), insomnia (n= 462,341), and female infertility (n=126,342) were extracted from the existing datasets and was analyzed through the two-sample mendelian randomization study. The following heterogeneity and sensitivity test were applied to ensure the robustness of results.

Results

Based on inverse variance weighted results, major depressive disorder was associated with female i

SUBMITTER: Mao D 

PROVIDER: S-EPMC11471633 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature