Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Pancreatitis is a serious and complex inflammatory disease that imposes a severe effect on quality of life. Links between plasma lipidome and pancreatitis have been reported, some of which have not yet been clearly elucidated.

Methods

Therefore, our study aimed to investigate the causal relationships between plasma lipidome and four types of pancreatitis by conducting a bidirectional, two-sample Mendelian randomization (MR) analysis. We obtained genetic variants associated with 179 lipid species from a Genome-wide association analysis of plasma lipidome. The aggregated statistical data of acute pancreatitis (AP), alcohol-induced acute pancreatitis (AAP), chronic pancreatitis (CP), and alcohol-induced chronic pancreatitis (ACP) from the FinnGen consortium were expl

SUBMITTER: Ma R 

PROVIDER: S-EPMC11471641 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature