RNA-Seq based selection signature analysis for identifying genomic footprints associated with the fat-tail phenotype in sheep.

ABSTRACT: Understanding the genetic background behind fat-tail development in sheep can be useful to develop breeding programs for genetic improvement, while the genetic basis of fat-tail formation is still not well understood. Here, to identify genomic regions influencing fat-tail size in sheep, a comprehensive selection signature identification analysis was performed through comparison of fat- and thin-tailed sheep breeds. Furthermore, to gain the first insights into the potential use of RNA-Seq for selection signature identification analysis, SNP calling was performed using RNA-Seq datasets. In total, 45 RNA-Seq samples from seven cohort studies were analyzed, and the F_ST method was used to detect selection signatures. Our findings indicated that RNA-Seq could be of potential utility f

SUBMITTER: Abbasabadi H 

PROVIDER: S-EPMC11471730 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature