Allergen immunotherapy using recombinant <i>Culicoides</i> allergens improves clinical signs of equine insect bite hypersensitivity.

ABSTRACT:

Introduction

Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis of horses caused by bites of Culicoides spp., sharing some common features with human atopic dermatitis. Allergen immunotherapy (AIT) using Culicoides whole-body extracts has limited efficacy. This study aimed to evaluate AIT with a pool of major Culicoides recombinant allergens in a prospective, double-blinded, placebo-controlled study.

Methods

The IBH lesion score was assessed during a pre-treatment year and first treatment year (May-October) in 17 horses and in May and July of a second treatment year. Nine horses were immunized subcutaneously 3× with a combination of nine r-allergens (20 μg each/injection) in alum and monophosphoryl lipid A (MPLA). Eight horses rece

SUBMITTER: Graner A 

PROVIDER: S-EPMC11471737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature