Deciphering the intracellular forces shaping mitochondrial motion.

ABSTRACT: We propose a novel quantitative method to explore the forces affecting mitochondria within living cells in an almost non-invasive fashion. This new tool enables the detection of localized mechanical impulses on these organelles that occur amidst the stationary fluctuations caused by the thermal jittering in the cytoplasm. Recent experimental evidence shows that the action of mechanical forces has important effects on the dynamics, morphology and distribution of mitochondria in cells. In particular, their crosstalk with the cytoskeleton has been found to alter these organelles function; however, the mechanisms underlying this phenomenon are largely unknown. Our results highlight the different functions that cytoskeletal networks play in shaping mitochondrial dynamics. This work presents a n

SUBMITTER: Fernandez Casafuz AB 

PROVIDER: S-EPMC11471753 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature