Neuronal activity in the ventral tegmental area during goal-directed navigation recorded by low-curvature microelectrode arrays.

ABSTRACT: Navigating toward destinations with rewards is a common behavior among animals. The ventral tegmental area (VTA) has been shown to be responsible for reward coding and reward cue learning, and its response to other variables, such as kinematics, has also been increasingly studied. These findings suggest a potential relationship between animal navigation behavior and VTA activity. However, the deep location and small volume of the VTA pose significant challenges to the precision of electrode implantation, increasing the uncertainty of measurement results during animal navigation and thus limiting research on the role of the VTA in goal-directed navigation. To address this gap, we innovatively designed and fabricated low-curvature microelectrode arrays (MEAs) via a novel backside dry etching

SUBMITTER: Xu W 

PROVIDER: S-EPMC11471829 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature