Current approaches and outstanding challenges of functional annotation of metabolites: a comprehensive review.

ABSTRACT: Metabolite profiling is a powerful approach for the clinical diagnosis of complex diseases, ranging from cardiometabolic diseases, cancer, and cognitive disorders to respiratory pathologies and conditions that involve dysregulated metabolism. Because of the importance of systems-level interpretation, many methods have been developed to identify biologically significant pathways using metabolomics data. In this review, we first describe a complete metabolomics workflow (sample preparation, data acquisition, pre-processing, downstream analysis, etc.). We then comprehensively review 24 approaches capable of performing functional analysis, including those that combine metabolomics data with other types of data to investigate the disease-relevant changes at multiple omics layers. We discuss the

SUBMITTER: Nguyen QH 

PROVIDER: S-EPMC11471905 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature