A practical assessment protocol for clinically relevant P-glycoprotein-mediated drug-drug interactions.

ABSTRACT:

Background

Drug-drug interactions (DDIs) may influence the effectiveness and safety of medication treatment, which may require additional monitoring, dose adjustment or avoidance of certain drugs. DDIs involving P-glycoprotein (P-gp) affect many drugs, but current official product information is often insufficient to guide the management of these DDIs in clinical practice. The aim of this paper is to describe a protocol to assess DDIs involving P-gp and to develop and implement practice recommendations for clinically relevant P-gp-mediated DDIs that affect clinical outcomes through changes in systemic drug exposure.

Methods

A combined literature review and expert opinion approach will be used according to the following seven steps: set up an expert panel (step 1), establish

SUBMITTER: Bogaard L 

PROVIDER: S-EPMC11472019 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature