ARTEMIS: a method for topology-independent superposition of RNA 3D structures and structure-based sequence alignment.

ABSTRACT: Non-coding RNAs play a major role in diverse processes in living cells with their sequence and spatial structure serving as the principal determinants of their function. Superposition of RNA 3D structures is the most accurate method for comparative analysis of RNA molecules and for inferring structure-based sequence alignments. Topology-independent superposition is particularly relevant, as evidenced by structurally similar RNAs with sequence permutations such as tRNA and Y RNA. To date, state-of-the-art methods for RNA 3D structure superposition rely on intricate heuristics, and the potential for topology-independent superposition has not been exhausted. Recently, we introduced the ARTEM method for unrestrained pairwise superposition of RNA 3D modules and now we developed it further to so

SUBMITTER: Bohdan DR 

PROVIDER: S-EPMC11472068 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature