Zinc and chitosan-enhanced β-tricalcium phosphate from calcined fetal bovine bone for mandible reconstruction.

ABSTRACT:

Background

Mandibular defects pose significant challenges in reconstructive surgery, and scaffold materials are increasingly recognized for their potential to address these challenges. Among various scaffold materials, Beta-tricalcium phosphate (β-TCP) is noted for its exceptional osteogenic properties. However, improvements in its biodegradation rate and mechanical strength are essential for optimal performance.

Methods

In this study, we developed a novel β-TCP-based scaffold, CFBB, by calcining fetal bovine cancellous bone. To enhance its properties, we modified CFBB with Chitosan (CS) and Zinc (Zn), creating three additional scaffold materials: CFBB/CS, CFBB/Zn²⁺, and CFBB/Zn²⁺/CS. We conducted comprehensive assessments of their physicochemical and m

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11472181 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature