The contribution of the vascular architecture and cerebrovascular reactivity to the BOLD signal formation across cortical depth.

ABSTRACT: Assessment of neuronal activity using blood oxygenation level-dependent (BOLD) is confounded by how the cerebrovascular architecture modulates hemodynamic responses. To understand brain function at the laminar level, it is crucial to distinguish neuronal signal contributions from those determined by the cortical vascular organization. Therefore, our aim was to investigate the purely vascular contribution in the BOLD signal by using vasoactive stimuli and compare that with neuronal-induced BOLD responses from a visual task. To do so, we estimated the hemodynamic response function (HRF) across cortical depth following brief visual stimulations under different conditions using ultrahigh-field (7 Tesla) functional (f)MRI. We acquired gradient-echo (GE)-echo-planar-imaging (EPI) BOLD, containin

SUBMITTER: Roefs ECA 

PROVIDER: S-EPMC11472217 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature