Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments.

ABSTRACT: Antioxidant nanozymes are powerful tools to combat oxidative stress, which can be further improved by applying nanozyme mixtures of multiple enzymatic function. Here, cocktails of Prussian blue (PB) nanocubes and copper(II) exchanged ZSM-5 zeolites (CuZ) with enhanced reactive oxygen species (ROS) scavenging activity were developed. Surface functionalization of the particles was performed using polymers to obtain stable colloids, i.e., resistant to aggregation, under a wide range of experimental conditions. The nanozyme cocktails possessed advanced antioxidant properties with multiple enzyme-like functions, catalyzing the decomposition of ROS in cascade reactions. The activity of the mixture far exceeded that of the individual particles, particularly in the peroxidase assay, where an impro

SUBMITTER: Halmagyi TG 

PROVIDER: S-EPMC11472261 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature