Deciphering the Interdomain Coupling in a Gram-Negative Bacterial Membrane Insertase.

ABSTRACT: YidC is a membrane protein that plays an important role in inserting newly generated proteins into lipid membranes. The Sec-dependent complex is responsible for inserting proteins into the lipid bilayer in bacteria. YidC facilitates the insertion and folding of membrane proteins, both in conjunction with the Sec complex and independently. Additionally, YidC acts as a chaperone during the folding of proteins. Multiple investigations have conclusively shown that Gram-positive bacterial YidC has Sec-independent insertion mechanisms. Through the use of microsecond-level all-atom molecular dynamics (MD) simulations, we have carried out an in-depth investigation of the YidC protein originating from Gram-negative bacteria. This research sheds light on the significance of multiple domains of the Y

SUBMITTER: Polasa A 

PROVIDER: S-EPMC11472308 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature