Sleep loss diminishes hippocampal reactivation and replay.

ABSTRACT: Memories benefit from sleep¹, and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process². However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power and higher frequency ripples. Pyramidal cells exhibited sustained firing during sleep deprivation and reduced firing during sleep, yet their firing rates were comparable during SWRs regardless of sleep state. Despite the robust firing and abundance of SWRs during sleep deprivation, we

SUBMITTER: Giri B 

PROVIDER: S-EPMC11472378 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature