Ketorolac Dose Ceiling Effect for Pediatric Headache in the Emergency Department.

ABSTRACT:

Objective

This study sought to demonstrate a non-inferiority analgesic ceiling effect previously -demonstrated within adults for pediatric patients receiving a maximum ketorolac dose of 15 mg.

Methods

We conducted a retrospective cohort study of pediatric ED patients weighing at least 60 kg treated with 30 mg (pre-intervention) or 15 mg (post-intervention) intravenous (IV) ketorolac for headache. The primary outcome included patient-reported pain scores. Additional outcomes included demographic variables, adjunct medication use and adverse effects. Categorical data were evaluated using a χ² test, and numerical data were evaluated using an ANOVA F test and Welch 2-sample t test.

Results

The pre- and post-intervention groups included 216 and 62 patient

SUBMITTER: Lefchak B 

PROVIDER: S-EPMC11472405 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature