Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity.

ABSTRACT:

Background

Nanoparticles are increasingly being used in medicine, cosmetics, food, and manufacturing. However, potential toxicity may limit the use of newly engineered nanoparticles. Prior studies have identified particle characteristics that are predictive of toxicity, although the mechanisms responsible for toxicity remain largely unknown. Nanoparticle treatment in cell culture, combined with high-throughput chemical screen allows for systematic perturbations of thousands of molecular targets against potential pathways of toxicity. The resulting data matrix, called chemical compendium, can provide insights into the mechanism of toxicity as well as help classify nanoparticles based on toxicity pathway.

Results

We performed unbiased screens of 1280 bioactive chemicals agains

SUBMITTER: Tran UT 

PROVIDER: S-EPMC11472441 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature