Outcome of Pneumocystis Jirovecii pneumonia (PcP) in post-CAR-T patients with hematological malignancies.

ABSTRACT:

Background

Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection associated with immunocompromised patients. The development of novel immunotherapies has promoted the incidence of PcP. This study describes the clinical course and outcome of PcP in chimeric antigen receptor (CAR) T cell recipients with hematological malignancies.

Methods

This is a retrospective case series of CAR-T recipients diagnosed with PcP in our center. The cases were all confirmed by metagenomic next-generation sequencing of clinical samples. The demographic, clinical, and outcome data were retrieved from the patients' medical charts and electronic medical record system.

Results

In total, 8 cases of PcP were identified. The underlying malignancies included T-acute lymphoblastic le

SUBMITTER: Zu C 

PROVIDER: S-EPMC11472446 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature