Serum lipidome reveals lipid metabolic dysregulation in severe fever with thrombocytopenia syndrome.

ABSTRACT:

Background

Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressing infectious disease with a high fatality rate caused by a novel bunyavirus (SFTSV). The role of lipids in viral infections is well-documented; however, the specific alterations in lipid metabolism during SFTSV infection remain elusive. This study aims to elucidate the lipid metabolic dysregulations in the early stages of SFTS patients.

Methods

This study prospectively collected peripheral blood sera from 11 critical SFTS patients, 37 mild SFTS patients, and 23 healthy controls during the early stages of infection for lipidomics analysis. A systematic bioinformatics analysis was conducted from three aspects integrating lipid differential expressions, lipid differential correlations, and lipi

SUBMITTER: Guo S 

PROVIDER: S-EPMC11472499 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature