Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma.

ABSTRACT:

Background

Chimeric antigen receptor (CAR)-NK cell therapy has shown remarkable clinical efficacy and safety in the treatment of hematological malignancies. However, this efficacy was limited in solid tumors owing to hostile tumor microenvironment (TME). Radiotherapy is commonly used for solid tumors and proved to improve the TME. Therefore, the combination with radiotherapy would be a potential strategy to improve therapeutic efficacy of CAR-NK cells for solid tumors.

Methods

Glypican-3 (GPC3) was used as a target antigen of CAR-NK cell for hepatocellular carcinoma (HCC). To promote migration towards HCC, CXCR2-armed CAR-NK92 cells targeting GPC3 were first developed, and their cytotoxic and migration activities towards HCC cells were evaluated. Next, the effects of irradia

SUBMITTER: Lin X 

PROVIDER: S-EPMC11472550 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature