Blood eosinophil count correlates with alveolar damage in emphysema-predominant COPD.

ABSTRACT:

Background

Although blood eosinophil count is recognized as a useful biomarker for the management of chronic obstructive pulmonary disease (COPD), the impact of eosinophils in COPD has not been fully elucidated. Here we aimed to investigate the relationships between the blood eosinophil count and various clinical parameters including lung structural changes.

Methods

Ninety-three COPD patients without concomitant asthma were prospectively enrolled in this study. Blood eosinophil count, serum IgE level, serum periostin level, and chest computed tomography (CT) scans were evaluated. Eosinophilic COPD was defined as COPD with a blood eosinophil count ≧ 300/µL. We examined the correlation between the blood eosinophil count and structural changes graded by chest CT, focusing speci

SUBMITTER: Nakamura S 

PROVIDER: S-EPMC11472558 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature