The PPOS protocol mitigates the detrimental effects of high BMI on embryo and clinical pregnancy outcomes.

ABSTRACT:

Background

The impact of high body mass index (BMI) on embryo and pregnancy outcomes in women using the PPOS (progestin-primed ovarian stimulation) protocol during their first frozen embryo transfer (FET) cycles is not clear. This study is to investigate the impact of BMI on oocyte, embryo, and pregnancy outcomes in patients who underwent the PPOS protocol.

Methods

This retrospective study included the first FET cycle of 22,392 patients following the PPOS protocol. The impact of BMI on oocyte and pregnancy outcomes was assessed across different BMI groups, using direct acyclic graph to determine covariates, followed by the application of multiple linear and logistic regressions to further validate this influence.

Results

The high BMI groups exhibited a higher number o

SUBMITTER: Shen X 

PROVIDER: S-EPMC11472598 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature