Bladder-preserving radiation therapy for patients with locally advanced and node-positive bladder cancer.

ABSTRACT:

Purpose

Trimodality therapy for muscle-invasive bladder cancer (MIBC) yields similar oncologic outcomes compared to radical cystectomy in appropriately selected patients; however, data regarding locally advanced MIBC (LA-MIBC) is limited. We explored our experience with LA-MIBC undergoing radiation therapy (RT).

Methods

We retrospectively identified 30 patients from an institutional prospectively collated database with non-metastatic, LA-MIBC. Patients with T3-4 N0 or T2-4 N + treated from 2012 to 2022 with definitive-intent RT, who were not candidates for cystectomy were included. Kaplan-Meier analysis was used to estimate time-to-event outcomes, and multivariate analyses were conducted using Cox proportional hazards modeling.

Results

43 % had T3N0 disease, 30 % had

SUBMITTER: Carriere P 

PROVIDER: S-EPMC11472623 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature