The ribosome profiling landscape of yeast reveals a high diversity in pervasive translation.

ABSTRACT:

Background

Pervasive translation is a widespread phenomenon that plays a critical role in the emergence of novel microproteins, but the diversity of translation patterns contributing to their generation remains unclear. Based on 54 ribosome profiling (Ribo-Seq) datasets, we investigated the yeast Ribo-Seq landscape using a representation framework that allows the comprehensive inventory and classification of the entire diversity of Ribo-Seq signals, including non-canonical ones.

Results

We show that if coding regions occupy specific areas of the Ribo-Seq landscape, noncoding regions encompass a wide diversity of Ribo-Seq signals and, conversely, populate the entire landscape. Our results show that pervasive translation can, nevertheless, be associated with high specificity,

SUBMITTER: Papadopoulos C 

PROVIDER: S-EPMC11472626 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature