Dioxygenase Chemistry in Nucleophilic Aldehyde Deformylations Utilizing Dicopper O₂-Derived Peroxide Complexes.

ABSTRACT: The chemistry of copper-dioxygen complexes is relevant to copper enzymes in biology as well as in (ligand)Cu-O₂ (or Cu₂-O₂) species utilized in oxidative transformations. For overall energy considerations, as applicable in chemical synthesis, it is beneficial to have an appropriate atom economy; both O-atoms of O_2(g) are transferred to the product(s). However, examples of such dioxygenase-type chemistry are extremely rare or not well documented. Herein, we report on nucleophilic oxidative aldehyde deformylation reactivity by the peroxo-dicopper(II) species [Cu₂^II(BPMPO^-)(O₂^2-)]¹⁺ {BPMPO-H = 2,6-bis{[(bis(2-pyridylmethyl)amino]methyl}-4-methylphenol)} and [Cu₂^II

SUBMITTER: Hota PK 

PROVIDER: S-EPMC11472664 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature