Prevalence of single-nucleotide variants in twenty-five pharmacogenes from a Cuban sample cohort.

ABSTRACT:

Introduction

The Cuban population is genetically diverse, and information on the prevalence of genetic variants is still limited. As complex admixture processes have occurred, we hypothesized that the frequency of pharmacogenetic variants and drug responses may vary within the country. The aims of the study were to describe the frequency distribution of 43 single-nucleotide variants (SNVs) from 25 genes of pharmacogenetic interest within the Cuba population and in relation to other populations, while taking into consideration some descriptive variables such as place of birth and skin color.

Materials and methods

SNVs were analyzed in 357 unrelated healthy Cuban volunteers. Genotype, allele frequencies, and ancestry proportions were determined, and the pairwise fixation index

SUBMITTER: Reyes-Reyes E 

PROVIDER: S-EPMC11472837 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature