A novel functionally graded bilayer membrane with excellent barrier function and <i>in vivo</i> osteogenesis promotion for guided bone regeneration.

ABSTRACT:

Introduction

Guided bone regeneration (GBR) technology has been widely used as a reliable method to address alveolar bone defects. To improve the clinical effects of GBR approach, there have been attempts to develop barrier membranes with enhanced regenerative properties. However, modifying the material and structure of GBR membranes to integrate physicochemical properties and biological activity remains challenging. The aim of this study was to develop a novel functionally graded bilayer membrane (FGBM) with a gradient structure and composition, and to evaluate its osteogenesis promotion effect for GBR.

Methods

By combining the phase inversion method and electrospinning method, functionally graded bilayer membranes (FGBM) with gradient structure and composition of poly(lact

SUBMITTER: Li J 

PROVIDER: S-EPMC11472855 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature