Depot-specific mRNA expression programs in human adipocytes suggest physiological specialization via distinct developmental programs.

ABSTRACT: Adipose tissue is distributed in diverse locations throughout the human body. Not much is known about the extent to which anatomically distinct adipose depots are functionally distinct, specialized organs, nor whether depot-specific characteristics result from intrinsic developmental programs, as opposed to reversible physiological responses to differences in tissue microenvironment. We used DNA microarrays to compare mRNA expression patterns of isolated human adipocytes and cultured adipose stem cells, before and after ex vivo adipocyte differentiation, from seven anatomically diverse adipose tissue depots. Adipocytes from different depots display distinct gene expression programs, which are most closely shared with anatomically related depots. mRNAs whose expression differs between anato

SUBMITTER: Clemons HJ 

PROVIDER: S-EPMC11472956 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature