A murine experimental model of the pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus.

ABSTRACT:

Background

The venom of Bothrops lanceolatus, a viperid species endemic to the Lesser Antillean Island of Martinique, induces thrombosis in a number of patients. Previous clinical observations indicate that thrombotic events are more common in patients bitten by juvenile specimens. There is a need to develop an experimental model of this effect in order to study the mechanisms involved.

Methodology/principal findings

The venoms of juvenile and adult specimens of B. lanceolatus were compared by (a) describing their proteome, (b) assessing their ability to induce thrombosis in a mouse model, and (c) evaluating their in vitro procoagulant activity and in vivo hemostasis alterations. Venom proteomes of juvenile and adult specimens were highly similar, albeit showing some differe

SUBMITTER: Rucavado A 

PROVIDER: S-EPMC11472959 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature