Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes.

ABSTRACT: Microglia are the brain-resident immune cells responsible for surveilling and protecting the central nervous system. These cells can express a wide array of immune genes, and that expression can become highly dynamic in response to changes in the environment, such as traumatic injury or neurological disease. Though microglial immune responses are well studied, we still do not know many mechanisms and regulators underlying all the varied microglial responses. Serpin E2 is a serine protease inhibitor that acts on a wide variety of serine proteases, with particularly potent affinity for the blood clotting enzyme thrombin. In the brain, Serpin E2 is highly expressed by many cell types, especially glia, and loss of Serpin E2 leads to behavioral changes as well as deficits in synaptic plasticity

SUBMITTER: Krawczyk MC 

PROVIDER: S-EPMC11473033 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature