Alterations in the Renin-Angiotensin System in Experimental Septic Shock.

ABSTRACT:

Objectives

To analyze dynamic changes in the renin-angiotensin system (RAS) during septic shock, focusing on angiotensin-converting enzyme (ACE) activity and the balance between angiotensin peptides, using a mass spectrometry method.

Design

Experimental septic shock model induced by peritonitis in swine.

Setting

Experimental Laboratory, Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles.

Subjects

Forty time points from eight mechanically ventilated pigs.

Interventions

Septic shock was induced using intraperitoneal instillation of autologous feces, followed by standardized fluid resuscitation, norepinephrine infusion, antibiotic administration, and peritoneal lavage.

Measurements and main results

The induction of sepsis re

SUBMITTER: Garcia B 

PROVIDER: S-EPMC11473057 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature