Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback.

ABSTRACT: Locomotion in mammals is directly controlled by the spinal neuronal network, operating under the control of supraspinal signals and somatosensory feedback that interact with each other. However, the functional architecture of the spinal locomotor network, its operation regimes, and the role of supraspinal and sensory feedback in different locomotor behaviors, including at different speeds, remain unclear. We developed a computational model of spinal locomotor circuits receiving supraspinal drives and limb sensory feedback that could reproduce multiple experimental data obtained in intact and spinal-transected cats during tied-belt and split-belt treadmill locomotion. We provide evidence that the spinal locomotor network operates in different regimes depending on locomotor speed. In an inta

SUBMITTER: Rybak IA 

PROVIDER: S-EPMC11473106 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature