High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries.

ABSTRACT:

Background

Even with increasing access to rapid HIV diagnosis and early antiretroviral therapy (ART) initiation, infants living with HIV seem to have adverse outcomes. We assessed the probability of death, viral suppression, and other HIV-related events in the first three years of life among early-treated children with perinatally-acquired HIV in South Africa, Mozambique, and Mali.

Methods

We enrolled a cohort of infants who initiated ART within the initial 6 months of life and within 3 months of diagnosis. These children were monitored 2, 6, 12 and 24 weeks after enrolment, followed by biannual check-ups up to 4 years after enrolment. We assessed the probability of death, viral load (VL) suppression, severe immunosuppression (according to WHO guidelines), and engagement in

SUBMITTER: Tagarro A 

PROVIDER: S-EPMC11473196 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature