Urinary anatalline and nicotelline cut-points to distinguish between exclusive and dual use of tobacco products.

ABSTRACT:

Objective

This study measured anatalline and nicotelline, two minor tobacco alkaloids, to discriminate between exclusive smokeless tobacco (SLT) use, exclusive electronic nicotine delivery systems (ENDS) use, exclusive cigarette use, dual SLT and cigarette use, and dual ENDS and cigarette use.

Methods

N = 664 urine samples from participants in the Population Assessment of Tobacco and Health Study were analyzed for anatalline and nicotelline. Geometric means and 95% confidence intervals were calculated for biomarker levels and their ratios. Non-parametric Receiver Operating Characteristic analyses were used to determine optimal cut-points of natural log-transformed biomarker ratios for distinguishing between tobacco use groups.

Results

The anatalline/nicotelline

SUBMITTER: Edwards KC 

PROVIDER: S-EPMC11473223 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature