Task-based default mode network connectivity predicts cognitive impairment and negative symptoms in first-episode schizophrenia.

ABSTRACT: Individuals diagnosed with schizophrenia (SZ) demonstrate difficulty distinguishing between internally and externally generated stimuli. These aberrations in "source monitoring" have been theorized as contributing to symptoms of the disorder, including hallucinations and delusions. Altered connectivity within the default mode network (DMN) of the brain has been proposed as a mechanism through which discrimination between self-generated and externally generated events is disrupted. Source monitoring abnormalities in SZ have additionally been linked to impairments in selective attention and inhibitory processing, which are reliably observed via the N100 component of the event-related brain potential elicited during an auditory paired-stimulus paradigm. Given overlapping constructs associated

SUBMITTER: Guha A 

PROVIDER: S-EPMC11473237 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature