A novel arginine methylation-associated lncRNA signature effectively predicts prognosis in breast cancer patients.

ABSTRACT: Breast cancer (BC) is a disease highly associated with epigenetic modification, and arginine methylation is particularly important in its genetic regulation. However, the role of arginine methylation related lncRNAs in breast cancer has not been studied. First, we identified the related lncRNAs (from TCGA database) according to the differentially expressed genes related to arginine methylation in breast cancer. Then the lncRNAs related to protein arginine methylation were obtained by regression analysis, and the risk score model was constructed. Finally, the cell experiment and subcutaneous tumor model verified that the arginine methylation related lncRNA z68871.1 in the model had a significant effect on the proliferation and invasion of breast cancer cells. In conclusion, we successfully

SUBMITTER: Wang C 

PROVIDER: S-EPMC11473254 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature