ASC speck serum concentrations, a component of sterile cellular inflammation, are associated with individual cardiopulmonary capacity.

ABSTRACT:

Aims

Exercise-induced cellular stress and sterile inflammation are of increasing interest. ASC specks are a component of the intracellular NLRP3-inflammasome and can be released into the blood. For example, serum ASC specks are increased after marathon running. We therefore tested whether ASC specks are potentially associated with the individual response to physical training and cardiopulmonary capacity.

Methods

We performed a prospective study in 45 healthy athletes. Blood samples were taken before and after cardiopulmonary exercise testing (CPET). ASC speck concentrations were quantitated using flow cytometry.

Results

Baseline ASC speck levels correlated with clinical parameters of body composition (height, weight, BMI) and parameters of cardiopulmonary performance

SUBMITTER: Kogel A 

PROVIDER: S-EPMC11473406 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature