Causal association between common rheumatic diseases and arrhythmia: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested a link between rheumatic diseases and arrhythmias. However, these studies have been limited by confounding factors and reverse causality, leaving the causal relationship between rheumatic diseases and arrhythmias uncertain. This study addresses this inquiry using genetic evidence.

Methods

Selected single nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS) data were employed as instrumental variables. Inverse variance weighting (IVW), MR-Egger regression, and the weighted median method were utilized in the two-sample Mendelian randomization analysis. Horizontal pleiotropy was identified and rectified through the MR-PRESSO test and MR-Egger regression. The stability and reliability of the Mendelian randomiza

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11473426 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature