Diet order significantly affects energy balance for diets varying in macronutrients but not ultraprocessing in crossover studies without a washout period.

ABSTRACT:

Background

Crossover studies can induce order effects, especially when they lack a washout period.

Objectives

We performed secondary analyses comparing groups of subjects randomly assigned to different diet orders in 2 inpatient crossover studies originally designed to compare within-subject differences in ad libitum energy intake. One study compared minimally processed low-carbohydrate (LC) compared with low-fat (LF) diets, and the other matched macronutrients and compared minimally processed food (MPF) with ultraprocessed food (UPF) diets.

Methods

Diet order group comparisons of changes in body weight and body composition, and differences in energy expenditure and food intake were assessed over 4 wk in 20 adults randomly assigned to either the LC followed immediatel

SUBMITTER: Sciarrillo CM 

PROVIDER: S-EPMC11473439 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature