RipE expression correlates with high ATP levels in <i>Ehrlichia</i>, which confers resistance during the extracellular stage to facilitate a new cycle of infection.

ABSTRACT: Ehrlichiosis is a potentially life-threatening disease caused by infection with the obligatory intracellular bacteria Ehrlichia species. Ehrlichia japonica infection of mice provides an animal model of ehrlichiosis as it recapitulates full-spectrum and lethal ehrlichiosis in humans. The E. japonica transposon mutant of EHF0962, which encodes a previously uncharacterized hypothetical protein, is attenuated in both infection and virulence in mice. EHF0962 was hence named here as resistance-inducing protein of Ehrlichia (RipE). Using this ΔripE mutant, we studied how RipE protein contributes to Ehrlichia pathogenesis. Ehrlichia species have an intracellular developmental cycle and a brief extracellular stage to initiate a new cycle of in

SUBMITTER: Chien RC 

PROVIDER: S-EPMC11473500 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature