A mathematical model simulating the adaptive immune response in various vaccines and vaccination strategies.

ABSTRACT: Vaccination has been widely recognized as an effective measure for preventing infectious diseases. To facilitate quantitative research into the activation of adaptive immune responses in the human body by vaccines, it is important to develop an appropriate mathematical model, which can provide valuable guidance for vaccine development. In this study, we constructed a novel mathematical model to simulate the dynamics of antibody levels following vaccination, based on principles from immunology. Our model offers a concise and accurate representation of the kinetics of antibody response. We conducted a comparative analysis of antibody dynamics within the body after administering several common vaccines, including traditional inactivated vaccines, mRNA vaccines, and future attenuated vaccines

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11473516 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature