Parvalbumin interneuron mGlu₅ receptors govern sex differences in prefrontal cortex physiology and binge drinking.

ABSTRACT: Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic mechanisms that guide these differences under basal conditions. The proper function of the prefrontal cortex (PFC) is essential for the top-down regulation of motivated behaviors. The activity of the PFC is tightly controlled by parvalbumin-expressing interneurons (PV-INs), a key subpopulation of fast-spiking GABAergic cells that regulate cortical excitability through direct innervations onto the perisomatic regions of nearby pyramidal cells. Recent rodent studies have identified notable sex differences in PV-IN activity and adaptations to experiences such as binge drinking. Here, we investigated the cellular and molecular mechanisms that underlie

SUBMITTER: Fabian CB 

PROVIDER: S-EPMC11473522 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature