Association between preventive treatment for unruptured intracranial aneurysms and incident dementia: a nationwide population-based cohort study.

ABSTRACT: Preventive treatments for unruptured intracranial aneurysms (UIAs) are used worldwide. However, the long-term effects to cognition have been underestimated. Using representative sample data from the National Health Insurance Service-Senior Cohort database, we compared cumulative risk of incident dementia between two groups: (1) treatment versus observation group, and (2) within the treatment group (surgical versus endovascular treatment). Cox proportional hazard ratios were estimated after applying one-to-one propensity score matching. Subgroup analyses were conducted to investigate interactions between treatment effects and sex, age and history of stroke, respectively. After matching, 3,763 participants were included in each group. The 10-year incidence rates of dementia were 9.82 and 8.6

SUBMITTER: Han HJ 

PROVIDER: S-EPMC11473528 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature