Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations.

ABSTRACT: We recorded dopamine release signals in centromedial and centrolateral sectors of the striatum as mice learned consecutive versions of visual cue-outcome conditioning tasks. Dopamine release responses differed for the centromedial and centrolateral sites. In neither sector could these be accounted for by classic reinforcement learning alone as classically applied to the activity of nigral dopamine-containing neurons. Medially, cue responses ranged from initial sharp peaks to modulated plateau responses; outcome (reward) responses during cue conditioning were minimal or, initially, negative. At centrolateral sites, by contrast, strong, transient dopamine release responses occurred at both cue and outcome. Prolonged, plateau release responses to cues emerged in both regions when discriminati

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC11473536 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature