Donor genetic burden for cerebrovascular risk and kidney transplant outcome.

ABSTRACT:

Background and hypothesis

Kidney grafts from donors who died of stroke and related traits have worse outcomes relative to grafts from both living donors and those who died of other causes. We hypothesise that deceased donors, particularly those who died of stroke, have elevated polygenic burden for cerebrovascular traits. We further hypothesise that this donor polygenic burden is associated with inferior graft outcomes in the recipient.

Methods

Using a dataset of 6666 deceased and living kidney donors from seven different European ancestry transplant cohorts, we investigated the role of polygenic burden for cerebrovascular traits (hypertension, stroke, and intracranial aneurysm (IA)) on donor age of death and recipient graft outcomes.

Results

We found that kidney dono

SUBMITTER: Collins KE 

PROVIDER: S-EPMC11473625 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature