Causal relationship between serum uric acid and cardiovascular disease: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have established an association between serum uric acid and cardiovascular disease (CVD). However, these studies are susceptible to uncontrolled confounders and reverse causality bias. To overcome these challenges, we employed a two-sample Mendelian randomization (MR) approach to investigate the causal link between serum uric acid and CVD.

Methods

We utilized Genome-wide association study (GWAS) data for serum uric acid and six CVD: coronary artery disease (CAD), hypertension, myocardial infarction (MI), heart failure (HF), angina, and coronary heart disease (CHD). MR analyses employed inverse variance weighting (IVW), MR-Egger, weighted median, and weighted model. Sensitivity analyses were conducted to assess result reliability, including Co

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11473680 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature